Passive immune neutralization strategies for prevention and control of influenza A infections
Identifieur interne : 000A28 ( Main/Exploration ); précédent : 000A27; suivant : 000A29Passive immune neutralization strategies for prevention and control of influenza A infections
Auteurs : Jianqiang Ye [États-Unis] ; Hongxia Shao [États-Unis, République populaire de Chine] ; Daniel R. Perez [États-Unis]Source :
- Immunotherapy [ 1750-743X ] ; 2012.
Abstract
Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1N1 pandemic), a significant delay in vaccine availability represents a significant public health concern, particularly in high-risk groups. The increasing emergence of strains resistant to the two major anti-influenza drugs, adamantanes and neuraminidase inhibitors, and the continuous circulation of avian influenza viruses with pandemic potential in poultry, strongly calls for alternative prophylactic and treatment options. In this review, we focus on passive virus neutralization strategies for the prevention and control of influenza type A viruses.
Url:
DOI: 10.2217/imt.11.167
PubMed: 22339460
PubMed Central: 3292042
Affiliations:
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Perez</name><affiliation wicri:level="4"><nlm:aff id="A1">Department of Veterinary Medicine, University of Maryland, College Park & Virginia – Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, College Park, MD 20742, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Veterinary Medicine, University of Maryland, College Park & Virginia – Maryland Regional College of Veterinary Medicine, 8075 Greenmead Drive, College Park, MD 20742</wicri:regionArea><placeName><region type="state">Maryland</region><settlement type="city">College Park (Maryland)</settlement></placeName><orgName type="university">Université du Maryland</orgName></affiliation></author></analytic><series><title level="j">Immunotherapy</title><idno type="ISSN">1750-743X</idno><idno type="eISSN">1750-7448</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1N1 pandemic), a significant delay in vaccine availability represents a significant public health concern, particularly in high-risk groups. The increasing emergence of strains resistant to the two major anti-influenza drugs, adamantanes and neuraminidase inhibitors, and the continuous circulation of avian influenza viruses with pandemic potential in poultry, strongly calls for alternative prophylactic and treatment options. 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Perez</name><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Shao, Hongxia" sort="Shao, Hongxia" uniqKey="Shao H" first="Hongxia" last="Shao">Hongxia Shao</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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